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"Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in obese and nonobese adults." JAMA

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In people with obesity and established cardiovascular disease but without diabetes, semaglutide 2.4 mg resulted in 20% reduction in major adverse cardiovascular events [(MACE), death from cardiovascular causes, nonfatal myocardial infarction or nonfatal stroke] compared to placebo (SELECT trial) after a mean follow-up of 39.8 months this is the first trial demonstrating cardiovascular benefit for an obesity pharmacotherapy [110]

and a discontinued oral GLP-1 programme (danuglipron) that was terminated in late 2023 due to gastrointestinal tolerability issues that prevented adequate dose escalation

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